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Chemical structure of Olverembatinib

GC62207

Olverembatinib

Also known as 4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[2-(1H-pyrazolo[5,4-b]pyridin-5-yl)ethynyl]benzamide

Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor· Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants· Olverembatinib strongly inhibits native Bcr-Abl and Bcr-AblT315I with IC50s of 0·34 nM and 0·68 nM, respectively· Olverembatinib has antitumor activity

ChemicalCAS1257628-77-5MW532.56FormulaC29H27F3N6O
CAS number
1257628-77-5
Molecular weight
532.56
Formula
C29H27F3N6O
Solubility
DMSO ： ≥ 100 mg/mL (187·77 mM)
InChIKey
TZKBVRDEOITLRB-UHFFFAOYSA-N
Catalogue number
GC62207
Brand
GLPBIO
Computed properties PubChem CID 51038269 · XLogP 4.6 · TPSA 77.2 Ų · H-bond donors 2
XLogP
4.6
TPSA
77.2 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
39

SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CC5=C(NN=C5)N=C4

Computed descriptors from PubChem (CID 51038269), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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