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Chemical structure of TD52

GC62191

TD52

Also known as 2-N,3-N-bis(3-ethynylphenyl)quinoxaline-2,3-diamine

TD52, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor· TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway· TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter· TD52 has less p-EGFR inhibition and has potent anti-cancer activity

ChemicalCAS1798328-24-1MW360.41FormulaC24H16N4
CAS number
1798328-24-1
Molecular weight
360.41
Formula
C24H16N4
InChIKey
SCUPZFSEJFWQIS-UHFFFAOYSA-N
Catalogue number
GC62191
Brand
GLPBIO
Computed properties PubChem CID 118656842 · XLogP 5.5 · TPSA 49.8 Ų · H-bond donors 2
XLogP
5.5
TPSA
49.8 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
28

SMILES C#CC1=CC(=CC=C1)NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(=C4)C#C

Computed descriptors from PubChem (CID 118656842), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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