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Chemical structure of KB02-SLF

GC62186

KB02-SLF

Also known as [(1R)-1-[3-[3-[2-[2-[[2-[[1-(2-chloroacetyl)-3,4-dihydro-2H-quinolin-6-yl]oxy]acetyl]amino]ethoxy]ethoxy]propanoylamino]phenyl]-3-(3,4-dimethoxyphenyl)propyl] (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate

KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue)· KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems· SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF

ChemicalCAS2384184-40-9MW949.52FormulaC50H65ClN4O12
CAS number
2384184-40-9
Molecular weight
949.52
Formula
C50H65ClN4O12
Solubility
DMSO ： 100 mg/mL (105·32 mM; Need ultrasonic)
InChIKey
OKJBKEQXKMMRPL-WVILEFPPSA-N
Catalogue number
GC62186
Brand
GLPBIO
Computed properties PubChem CID 137347727 · XLogP 6.1 · TPSA 188 Ų · H-bond donors 2
XLogP
6.1
TPSA
188 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
26
Heavy atoms
67

SMILES CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)NC(=O)CCOCCOCCNC(=O)COC4=CC5=C(C=C4)N(CCC5)C(=O)CCl

Computed descriptors from PubChem (CID 137347727), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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