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Chemical structure of XST-14

GC62146

XST-14

Also known as methyl 4,6-di(propan-2-yloxy)-1H-indole-2-carboxylate

XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26·6 nM· XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate· XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects

ChemicalCAS2607143-50-8MW291.34FormulaC16H21NO4
CAS number
2607143-50-8
Molecular weight
291.34
Formula
C16H21NO4
Solubility
DMSO : 250 mg/mL (858·10 mM; Need ultrasonic)
InChIKey
ZNFMBFABCSHXPM-UHFFFAOYSA-N
Catalogue number
GC62146
Brand
GLPBIO
Computed properties PubChem CID 155291452 · XLogP 3.8 · TPSA 60.6 Ų · H-bond donors 1
XLogP
3.8
TPSA
60.6 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
21

SMILES CC(C)OC1=CC2=C(C=C(N2)C(=O)OC)C(=C1)OC(C)C

Computed descriptors from PubChem (CID 155291452), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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