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Chemical structure of Chiauranib

GC62145

Chiauranib

Also known as N-(2-aminophenyl)-6-(7-methoxyquinolin-4-yl)oxynaphthalene-1-carboxamide

Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis· Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM· Chiauranib has strongly anticancer effects

ChemicalCAS1256349-48-0MW435.47FormulaC27H21N3O3
CAS number
1256349-48-0
Molecular weight
435.47
Formula
C27H21N3O3
Solubility
DMSO ： 62·5 mg/mL (143·52 mM; Need ultrasonic)
InChIKey
BRKWREZNORONDU-UHFFFAOYSA-N
Catalogue number
GC62145
Brand
GLPBIO
Computed properties PubChem CID 49779393 · XLogP 5.1 · TPSA 86.5 Ų · H-bond donors 2
XLogP
5.1
TPSA
86.5 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
33

SMILES COC1=CC2=NC=CC(=C2C=C1)OC3=CC4=C(C=C3)C(=CC=C4)C(=O)NC5=CC=CC=C5N

Computed descriptors from PubChem (CID 49779393), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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