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Chemical structure of Venadaparib

GC62129

Venadaparib

Also known as 4-[[3-[3-[(cyclopropylamino)methyl]azetidine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1·4 nM and 1·0 nM for PARP1 and PARP2, respectively· Venadaparib does not sensitive to PARP-5· Venadaparib prevents the repair of DNA single-strand breaks (SSB) and can be used for solid tumors research

ChemicalCAS1681017-83-3MW406.45FormulaC23H23FN4O2
CAS number
1681017-83-3
Molecular weight
406.45
Formula
C23H23FN4O2
Solubility
DMSO ： 100 mg/mL (246·03 mM; Need ultrasonic)
InChIKey
YNBQAYKYNYRCCA-UHFFFAOYSA-N
Catalogue number
GC62129
Brand
GLPBIO
Computed properties PubChem CID 117955898 · XLogP 2.3 · TPSA 73.8 Ų · H-bond donors 2
XLogP
2.3
TPSA
73.8 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
30

SMILES C1CC1NCC2CN(C2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Computed descriptors from PubChem (CID 117955898), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.