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Chemical structure of OPC-14523 hydrochloride

GC61889

OPC-14523 hydrochloride

Also known as 1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydroquinolin-2-one;hydrochloride

OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2·3 nM), and the 5-HT transporter (IC50=80 nM)

ChemicalCAS145969-31-9MW450.4FormulaC23H29Cl2N3O2
CAS number
145969-31-9
Molecular weight
450.4
Formula
C23H29Cl2N3O2
Solubility
DMSO ： 83·33 mg/mL (185·01 mM)
InChIKey
SFOVXVXPFWJNBL-UHFFFAOYSA-N
Catalogue number
GC61889
Brand
GLPBIO
Computed properties PubChem CID 19027727 · TPSA 36 Ų · H-bond donors 1 · H-bond acceptors 4
TPSA
36 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
30

SMILES COC1=CC=CC2=C1CCC(=O)N2CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl

Computed descriptors from PubChem (CID 19027727), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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