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Chemical structure of Verucopeptin

GC61863

Verucopeptin

Also known as (2S)-2-hydroxy-N-[(3S,4S,19R)-17-hydroxy-8,14-dimethyl-2,6,9,12,15,18-hexaoxo-4-propan-2-yl-5-oxa-1,8,11,14,17,23-hexazabicyclo[17.4.0]tricosan-3-yl]-2-[(5S,6R)-2-hydroxy-5-methoxy-6-[(E,4S,6S,8R)-4,6,8-trimethyldec-2-en-2-yl]oxan-2-yl]propanamide

Verucopeptin is a potent?HIF-1 (IC50=0·22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels· Verucopeptin strongly inhibits v-ATPase activity?by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D· Verucopeptin exhibits antitumor activity against multidrug resistance (MDR)?cancers and can be used for cancer research

ChemicalCAS138067-14-8MW896.08FormulaC43H73N7O13
CAS number
138067-14-8
Molecular weight
896.08
Formula
C43H73N7O13
InChIKey
IKTLLLGZSOKVRF-GWALSTOSSA-N
Catalogue number
GC61863
Brand
GLPBIO
Computed properties PubChem CID 121231434 · XLogP 3.1 · TPSA 257 Ų · H-bond donors 6
XLogP
3.1
TPSA
257 Ų
H-bond donors
6
H-bond acceptors
14
Rotatable bonds
12
Heavy atoms
63

SMILES CC[C@@H](C)C[C@H](C)C[C@H](C)/C=C(\C)/[C@@H]1[C@H](CCC(O1)([C@@](C)(C(=O)N[C@H]2[C@@H](OC(=O)CN(C(=O)CNC(=O)CN(C(=O)CN(C(=O)[C@H]3CCCNN3C2=O)O)C)C)C(C)C)O)O)OC

Computed descriptors from PubChem (CID 121231434), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.