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Chemical structure of Pomalidomide-PEG2-azide

GC61617

Pomalidomide-PEG2-azide

Also known as 2-[2-(2-azidoethoxy)ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide

Pomalidomide-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate that includes a Pomalidomide-based cereblon ligand and a 2-unit PEG linker used in proteolysis targeting chimeras (PROTAC) technology· Pomalidomide-PEG2-azide is a click chemistry reagent containing an azide group that can react with alkynyl-containing molecules via a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction

ChemicalCAS2267306-14-7MW444.4FormulaC19H20N6O7
CAS number
2267306-14-7
Molecular weight
444.4
Formula
C19H20N6O7
Solubility
DMSO： 90 mg/mL (202·52 mM)
InChIKey
QMQAWNMGKYQDLT-UHFFFAOYSA-N
Catalogue number
GC61617
Brand
GLPBIO
Computed properties PubChem CID 155292127 · XLogP 0.5 · TPSA 145 Ų · H-bond donors 2
XLogP
0.5
TPSA
145 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
10
Heavy atoms
32

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)COCCOCCN=[N+]=[N-]

Computed descriptors from PubChem (CID 155292127), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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