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Chemical structure of CMLD-2

GC61567

CMLD-2

Also known as 5,7-dimethoxy-8-[1-(4-methoxyphenyl)-3-oxo-3-pyrrolidin-1-ylpropyl]-4-phenylchromen-2-one

CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM)· CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines· Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation

ChemicalCAS958843-91-9MW513.58FormulaC31H31NO6
CAS number
958843-91-9
Molecular weight
513.58
Formula
C31H31NO6
Solubility
DMSO： 50 mg/mL (97·36 mM)
InChIKey
PROGRNRRJJYCNX-UHFFFAOYSA-N
Catalogue number
GC61567
Brand
GLPBIO
Computed properties PubChem CID 16746438 · XLogP 4.6 · TPSA 74.3 Ų · H-bond donors 0
XLogP
4.6
TPSA
74.3 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
38

SMILES COC1=CC=C(C=C1)C(CC(=O)N2CCCC2)C3=C(C=C(C4=C3OC(=O)C=C4C5=CC=CC=C5)OC)OC

Computed descriptors from PubChem (CID 16746438), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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