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Chemical structure of Indophagolin

GC61565

Indophagolin

Also known as 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropanecarbonyl)-2,3-dihydroindole-6-sulfonamide

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM)· Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2·71, 2·40 and 3·49 μM, respectively· Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3·4~15·4 μM)· Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1·0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7

ChemicalCAS1207660-00-1MW523.75FormulaC19H15BrClF3N2O3S
CAS number
1207660-00-1
Molecular weight
523.75
Formula
C19H15BrClF3N2O3S
InChIKey
OGXJZCDFFBDSJJ-UHFFFAOYSA-N
Catalogue number
GC61565
Brand
GLPBIO
Computed properties PubChem CID 46504926 · XLogP 4.5 · TPSA 74.9 Ų · H-bond donors 1
XLogP
4.5
TPSA
74.9 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
30

SMILES C1CC1C(=O)N2CCC3=CC(=C(C=C32)S(=O)(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F)Br

Computed descriptors from PubChem (CID 46504926), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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