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Chemical structure of Palosuran hydrochloride

GC61546

Palosuran hydrochloride

Also known as 1-[2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea;hydrochloride

Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3·6 nM for CHO cell membranes expressing human recombinant receptors

ChemicalCAS2469274-58-4MW454.99FormulaC25H31ClN4O2
CAS number
2469274-58-4
Molecular weight
454.99
Formula
C25H31ClN4O2
Solubility
DMSO： 50 mg/mL (109·89 mM); Water： 7·14 mg/mL (15·69 mM)
InChIKey
VXRLVUHHXKVQSQ-UHFFFAOYSA-N
Catalogue number
GC61546
Brand
GLPBIO
Computed properties PubChem CID 137891318 · TPSA 77.5 Ų · H-bond donors 4 · H-bond acceptors 4
TPSA
77.5 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
32

SMILES CC1=NC2=CC=CC=C2C(=C1)NC(=O)NCCN3CCC(CC3)(CC4=CC=CC=C4)O.Cl

Computed descriptors from PubChem (CID 137891318), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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