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Chemical structure of SC-43

GC61524

SC-43

Also known as 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea

SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist· SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis· SC-43 has anti-fibrotic and anticancer effects

ChemicalCAS1400989-25-4MW431.8FormulaC21H13ClF3N3O2
CAS number
1400989-25-4
Molecular weight
431.8
Formula
C21H13ClF3N3O2
Solubility
DMSO： 250 mg/mL (578·97 mM)
InChIKey
QIBWSQJZKMUZAK-UHFFFAOYSA-N
Catalogue number
GC61524
Brand
GLPBIO
Computed properties PubChem CID 70688629 · XLogP 6 · TPSA 74.2 Ų · H-bond donors 2
XLogP
6
TPSA
74.2 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
30

SMILES C1=CC(=CC(=C1)OC2=CC=C(C=C2)C#N)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Computed descriptors from PubChem (CID 70688629), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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