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Chemical structure of VH032

GC61452

VH032

Also known as (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein· VH032 is a VHL/HIF-1α interaction inhibitor with a Kd＜/b of 185 nM· VH032 can be connected to the ligand for protein by a linker to form PROTACs

ChemicalCAS1448188-62-2MW472.6FormulaC24H32N4O4S
CAS number
1448188-62-2
Molecular weight
472.6
Formula
C24H32N4O4S
Solubility
DMSO： 200 mg/mL (423·19 mM)
InChIKey
GFVIEZBZIUKYOG-SVFBPWRDSA-N
Catalogue number
GC61452
Brand
GLPBIO
Computed properties PubChem CID 77232228 · XLogP 2.3 · TPSA 140 Ų · H-bond donors 3
XLogP
2.3
TPSA
140 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
33

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C)O

Computed descriptors from PubChem (CID 77232228), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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