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Chemical structure of yGsy2p-IN-H23

GC61406

yGsy2p-IN-H23

Also known as 2-methoxy-4-[3-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-phenylimidazol-4-yl]phenol

yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 ?M for human glycogen synthase 1 (hGYS1)

ChemicalCAS1269190-98-8MW377.48FormulaC23H27N3O2
CAS number
1269190-98-8
Molecular weight
377.48
Formula
C23H27N3O2
Solubility
DMSO : 100 mg/mL (264·91 mM; Need ultrasonic)
InChIKey
YGPHAIXUDLLWHC-UHFFFAOYSA-N
Catalogue number
GC61406
Brand
GLPBIO
Computed properties PubChem CID 50985590 · XLogP 3.8 · TPSA 50.5 Ų · H-bond donors 1
XLogP
3.8
TPSA
50.5 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
28

SMILES CN1CCCC1CCN2C=NC(=C2C3=CC(=C(C=C3)O)OC)C4=CC=CC=C4

Computed descriptors from PubChem (CID 50985590), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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