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Chemical structure of XZ739

GC61384

XZ739

Also known as 4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl-methylamino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide

XZ739, a Cereblon-dependent PROTAC BCL-XL (Bcl-2 family member) degrader with a DC50 value of 2·5 nM in MOLT-4 cells after 16 h treatment· XZ739 also induces cell death through caspase-mediated apoptosis

ChemicalCAS2365172-19-4MW1349.99FormulaC65H76ClF3N8O12S3
CAS number
2365172-19-4
Molecular weight
1349.99
Formula
C65H76ClF3N8O12S3
Solubility
DMSO： 20 mg/mL (14·81 mM)
InChIKey
RTASGZOITGGVPZ-YJUSKGKKSA-N
Catalogue number
GC61384
Brand
GLPBIO
Computed properties PubChem CID 139331521 · XLogP 9.9 · TPSA 284 Ų · H-bond donors 4
XLogP
9.9
TPSA
284 Ų
H-bond donors
4
H-bond acceptors
21
Rotatable bonds
30
Heavy atoms
92

SMILES CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN(C)CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)CSC8=CC=CC=C8)S(=O)(=O)C(F)(F)F)C9=CC=C(C=C9)Cl)C

Computed descriptors from PubChem (CID 139331521), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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