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Chemical structure of WF-47-JS03

GC61381

WF-47-JS03

Also known as 3-(3,4-dimethoxyphenyl)-5-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine

WF-47-JS03 is a potent and selective RET kinase inhibitor with IC50s of 1·7 nM and 5·3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively· WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR)· Effective brain penetration

ChemicalCAS2561413-77-0MW514.66FormulaC30H38N6O2
CAS number
2561413-77-0
Molecular weight
514.66
Formula
C30H38N6O2
InChIKey
YRBWLEAMGAGYBK-UHFFFAOYSA-N
Catalogue number
GC61381
Brand
GLPBIO
Computed properties PubChem CID 145996543 · XLogP 5.3 · TPSA 89.9 Ų · H-bond donors 2
XLogP
5.3
TPSA
89.9 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
38

SMILES CC1(CC(CC(N1C)(C)C)NC2=NC3=C(C=NN3C(=C2C4=CC=CC=C4)N)C5=CC(=C(C=C5)OC)OC)C

Computed descriptors from PubChem (CID 145996543), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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