GC61266
SAR-020106
Also known as 5-[(8-chloroisoquinolin-3-yl)amino]-3-[(2R)-1-(dimethylamino)propan-2-yl]oxypyrazine-2-carbonitrile
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13·3 nM for human CHK1· SAR-020106 shows excellent selectivity over CHK2· SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion· SAR-020106 can enhance antitumor activity with selected anticancer drugs
ChemicalCAS1184843-57-9MW382.85FormulaC19H19ClN6O
- CAS number
- 1184843-57-9
- Molecular weight
- 382.85
- Formula
- C19H19ClN6O
- Solubility
- DMSO： 5 mg/mL (13·06 mM)
- InChIKey
- SRBJWIBAMIKCMV-GFCCVEGCSA-N
- Catalogue number
- GC61266
- Brand
- GLPBIO
Computed properties PubChem CID 44203948 · XLogP 3.6 · TPSA 87 Ų · H-bond donors 1
- XLogP
- 3.6
- TPSA
- 87 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 27
SMILES C[C@H](CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C3C(=C2)C=CC=C3Cl
Computed descriptors from PubChem (CID 44203948), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il