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Chemical structure of Pyrazoloacridine

GC61224

Pyrazoloacridine

Also known as 3-(4-methoxy-10-nitro-8,14,15-triazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-14-yl)-N,N-dimethylpropan-1-amine

Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2· Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1·25 μM in K562 myeloid leukemia cells for 24 h treatment

ChemicalCAS99009-20-8MW367.4FormulaC19H21N5O3
CAS number
99009-20-8
Molecular weight
367.4
Formula
C19H21N5O3
InChIKey
HZCWPKGYTCJSEB-UHFFFAOYSA-N
Catalogue number
GC61224
Brand
GLPBIO
Computed properties PubChem CID 339455 · XLogP 3 · TPSA 88.1 Ų · H-bond donors 1
XLogP
3
TPSA
88.1 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
27

SMILES CN(C)CCCN1C2=C3C(=C(C=C2)[N+](=O)[O-])NC4=C(C3=N1)C=C(C=C4)OC

Computed descriptors from PubChem (CID 339455), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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