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Chemical structure of PROTAC BRD4 Degrader-5

GC61212

PROTAC BRD4 Degrader-5

Also known as (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4· PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines

ChemicalCAS2409538-70-9MW1016.67FormulaC50H62ClN9O8S2
CAS number
2409538-70-9
Molecular weight
1016.67
Formula
C50H62ClN9O8S2
Solubility
DMSO： 145 mg/mL (142·62 mM); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
SLPWRCRRHVRNRM-BEGQQDOQSA-N
Catalogue number
GC61212
Brand
GLPBIO
Computed properties PubChem CID 146673078 · XLogP 5.4 · TPSA 268 Ų · H-bond donors 4
XLogP
5.4
TPSA
268 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
21
Heavy atoms
70

SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)N[C@@H](C)C5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C

Computed descriptors from PubChem (CID 146673078), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.