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Chemical structure of Pomalidomide-PEG1-C2-N3

GC61200

Pomalidomide-PEG1-C2-N3

Also known as 4-[2-(2-azidoethoxy)ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology· Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10· CP-10 induces the degradation of CDK6 with an DC50 of 2·1 nM

ChemicalCAS2271036-44-1MW386.36FormulaC17H18N6O5
CAS number
2271036-44-1
Molecular weight
386.36
Formula
C17H18N6O5
InChIKey
NJPMWHWTBBYBDY-UHFFFAOYSA-N
Catalogue number
GC61200
Brand
GLPBIO
Computed properties PubChem CID 138857982 · XLogP 1.6 · TPSA 119 Ų · H-bond donors 2
XLogP
1.6
TPSA
119 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
28

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCN=[N+]=[N-]

Computed descriptors from PubChem (CID 138857982), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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