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Chemical structure of MG-277

GC61060

MG-277

MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC50 of 1·3 nM· MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC50s of 3·5 nM for RS4;11 cells and 3·4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively· Anticancer activity

ChemicalCAS2411085-89-5MW774.71FormulaC41H42Cl2FN5O5
CAS number
2411085-89-5
Molecular weight
774.71
Formula
C41H42Cl2FN5O5
InChIKey
BANRYGZZIMCKNA-OYGJEQPESA-N
Catalogue number
GC61060
Brand
GLPBIO
Computed properties PubChem CID 139600332 · XLogP 5.6 · TPSA 137 Ų · H-bond donors 4
XLogP
5.6
TPSA
137 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
54

SMILES C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NCCCCCC4=C5CN(C(=O)C5=CC=C4)C6CCC(=O)NC6=O)C7=C(C(=CC=C7)Cl)F)C8=C(C=C(C=C8)Cl)NC3=O

Computed descriptors from PubChem (CID 139600332), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.