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Chemical structure of JC-171

GC60958

JC-171

Also known as 5-chloro-N-[2-[4-(hydroxysulfamoyl)phenyl]ethyl]-2-methoxybenzamide

JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8·45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A·1 macrophages

ChemicalCAS2112809-98-8MW384.83FormulaC16H17ClN2O5S
CAS number
2112809-98-8
Molecular weight
384.83
Formula
C16H17ClN2O5S
Solubility
DMSO： 250 mg/mL (649·64 mM)
InChIKey
KQRQPMUPYDOTCA-UHFFFAOYSA-N
Catalogue number
GC60958
Brand
GLPBIO
Computed properties PubChem CID 134600183 · XLogP 2.3 · TPSA 113 Ų · H-bond donors 3
XLogP
2.3
TPSA
113 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
7
Heavy atoms
25

SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NO

Computed descriptors from PubChem (CID 134600183), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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