Loading...
Chemical structure of GW406108X

GC60891

GW406108X

Also known as (3Z)-3-[(3,5-dichloro-4-hydroxyphenyl)methylidene]-5-(furan-2-carbonyl)-1H-indol-2-one

GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0·82 uM in ATPase assays· GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6·37 (427 nM)· GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK

ChemicalCAS1644443-92-4MW400.21FormulaC20H11Cl2NO4
CAS number
1644443-92-4
Molecular weight
400.21
Formula
C20H11Cl2NO4
Solubility
DMSO： 62·5 mg/mL (156·17 mM)
InChIKey
XKTUKRBLWOHYIL-MLPAPPSSSA-N
Catalogue number
GC60891
Brand
GLPBIO
Computed properties PubChem CID 44312236 · XLogP 4.5 · TPSA 79.5 Ų · H-bond donors 2
XLogP
4.5
TPSA
79.5 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
27

SMILES C1=COC(=C1)C(=O)C2=CC\3=C(C=C2)NC(=O)/C3=C\C4=CC(=C(C(=C4)Cl)O)Cl

Computed descriptors from PubChem (CID 44312236), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.