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Chemical structure of FKBP12 PROTAC RC32

GC60843

FKBP12 PROTAC RC32

Also known as (1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-12-[(2R)-1-[(1S,3R,4R)-4-[2-[[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]methoxy]ethoxy]-3-methoxycyclohexyl]propan-2-yl]-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology· FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an Cereblon E3 ubiquitin ligase

ChemicalCAS2375555-66-9MW1426.69FormulaC75H107N7O20
CAS number
2375555-66-9
Molecular weight
1426.69
Formula
C75H107N7O20
Solubility
DMSO： 10 mg/mL (7·01 mM)
InChIKey
XCSUEITWRRFFMN-LPIXFUNRSA-N
Catalogue number
GC60843
Brand
GLPBIO
Computed properties PubChem CID 156599864 · XLogP 5.8 · TPSA 338 Ų · H-bond donors 4
XLogP
5.8
TPSA
338 Ų
H-bond donors
4
H-bond acceptors
23
Rotatable bonds
23
Heavy atoms
102

SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C\C=C/C=C\[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C\[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCOCC5=CN(N=N5)CCOCCOCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)C)/C)O)OC)C)C)/C)OC

Computed descriptors from PubChem (CID 156599864), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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