GC60759
Desmorpholinyl Navitoclax-NH-Me
Also known as 4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(methylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor· Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739
ChemicalCAS2365172-82-1MW918.55FormulaC44H51ClF3N5O5S3
- CAS number
- 2365172-82-1
- Molecular weight
- 918.55
- Formula
- C44H51ClF3N5O5S3
- Solubility
- DMSO： 100 mg/mL (108·87 mM); Water： ＜ 0·1 mg/mL (insoluble)
- InChIKey
- CNTHZPROCQHGOX-PGUFJCEWSA-N
- Catalogue number
- GC60759
- Brand
- GLPBIO
Computed properties PubChem CID 139331525 · XLogP 9.5 · TPSA 170 Ų · H-bond donors 3
- XLogP
- 9.5
- TPSA
- 170 Ų
- H-bond donors
- 3
- H-bond acceptors
- 13
- Rotatable bonds
- 16
- Heavy atoms
- 61
SMILES CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCNC)CSC5=CC=CC=C5)S(=O)(=O)C(F)(F)F)C6=CC=C(C=C6)Cl)C
Computed descriptors from PubChem (CID 139331525), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
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- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
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- Questions
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