GC60629
BDTX-189
Also known as N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7-(2-morpholin-4-ylethoxy)quinazolin-6-yl]prop-2-enamide
BDTX-189 (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants· BDTX-189 shows KDs of 0·2, 0·76, 13 and 1·2 nM for EGFR, HER2, BLK and RIPK2, reapectively· Anticancer activity
ChemicalCAS2414572-47-5MW561.03FormulaC29H29ClN6O4
- CAS number
- 2414572-47-5
- Molecular weight
- 561.03
- Formula
- C29H29ClN6O4
- InChIKey
- HIBPKFXWOPYJPZ-UHFFFAOYSA-N
- Catalogue number
- GC60629
- Brand
- GLPBIO
Computed properties PubChem CID 154824631 · XLogP 3.9 · TPSA 111 Ų · H-bond donors 2
- XLogP
- 3.9
- TPSA
- 111 Ų
- H-bond donors
- 2
- H-bond acceptors
- 9
- Rotatable bonds
- 11
- Heavy atoms
- 40
SMILES C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)OCCN5CCOCC5
Computed descriptors from PubChem (CID 154824631), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il