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Chemical structure of CTLA-4 inhibitor

GC60618

CTLA-4 inhibitor

Also listed as B7/CD28 interaction inhibitor 1

B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7·1-CD28 interaction inhibitor with an IC50 of 50 nM

ChemicalCAS635324-72-0MW427.35FormulaC21H13F4N5O
CAS number
635324-72-0
Molecular weight
427.35
Formula
C21H13F4N5O
Solubility
DMSO ： 62·5 mg/mL (146·25 mM; Need ultrasonic)
InChIKey
WQKVVTLTCHDAST-UHFFFAOYSA-N
Catalogue number
GC60618
Brand
GLPBIO
Computed properties PubChem CID 101136468 · XLogP 4.5 · TPSA 63.1 Ų · H-bond donors 1
XLogP
4.5
TPSA
63.1 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
2
Heavy atoms
31

SMILES CN1C2=NC(=C3C(=C2C=N1)NN(C3=O)C4=CC=C(C=C4)F)C5=CC(=CC=C5)C(F)(F)F

Computed descriptors from PubChem (CID 101136468), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.