GC60567
Afatinib impurity 11
Also known as N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]prop-2-enamide
Afatinib impurity 11 is an impurity of Afatinib· Afatinib is an irreversible EGFR family inhibitor with IC50s of 0·5 nM, 0·4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively
ChemicalCAS1402086-20-7MW428.84FormulaC21H18ClFN4O3
- CAS number
- 1402086-20-7
- Molecular weight
- 428.84
- Formula
- C21H18ClFN4O3
- InChIKey
- MLHDLQIHGCIPJQ-ZDUSSCGKSA-N
- Catalogue number
- GC60567
- Brand
- GLPBIO
Computed properties PubChem CID 66555110 · XLogP 3.9 · TPSA 85.4 Ų · H-bond donors 2
- XLogP
- 3.9
- TPSA
- 85.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 30
SMILES C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Computed descriptors from PubChem (CID 66555110), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il