Loading...
Chemical structure of (5Z,2E)-CU-3

GC60397

(5Z,2E)-CU-3

Also known as N-[(5Z)-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzenesulfonamide

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0·6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0·48 mM· (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα· (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells

ChemicalCAS1815598-71-0MW392.47FormulaC16H12N2O4S3
CAS number
1815598-71-0
Molecular weight
392.47
Formula
C16H12N2O4S3
Solubility
DMSO： 20 mg/mL (50·96 mM; ultrasonic and warming and heat to 60°C); Water： ＜ 0·1 mg/mL (insoluble)
InChIKey
YIUMXULORVBWLL-SPGDJUBISA-N
Catalogue number
GC60397
Brand
GLPBIO
Computed properties PubChem CID 6393804 · XLogP 3.6 · TPSA 145 Ų · H-bond donors 1
XLogP
3.6
TPSA
145 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
25

SMILES C1=CC=C(C=C1)S(=O)(=O)NN2C(=O)/C(=C/C=C/C3=CC=CO3)/SC2=S

Computed descriptors from PubChem (CID 6393804), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.