Loading...
Chemical structure of TBAP-001

GC60355

TBAP-001

Also known as 1-[3-tert-butyl-1-(3-fluorophenyl)pyrazol-5-yl]-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea

TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay

ChemicalCAS1777832-90-2MW531.51FormulaC27H23F2N7O3
CAS number
1777832-90-2
Molecular weight
531.51
Formula
C27H23F2N7O3
InChIKey
AJFKKXIBHCRFJO-UHFFFAOYSA-N
Catalogue number
GC60355
Brand
GLPBIO
Computed properties PubChem CID 91799359 · XLogP 4.3 · TPSA 123 Ų · H-bond donors 3
XLogP
4.3
TPSA
123 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
39

SMILES CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C(=NC=C3)NC(=O)C=N4)F)C5=CC(=CC=C5)F

Computed descriptors from PubChem (CID 91799359), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.