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Chemical structure of Supinoxin

GC60348

Supinoxin

Also known as 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide

Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent· Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin· Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM

ChemicalCAS888478-45-3MW441.46FormulaC22H24FN5O4
CAS number
888478-45-3
Molecular weight
441.46
Formula
C22H24FN5O4
InChIKey
KAKPGJJRYRYSTP-UHFFFAOYSA-N
Catalogue number
GC60348
Brand
GLPBIO
Computed properties PubChem CID 11619093 · XLogP 2.7 · TPSA 89.1 Ų · H-bond donors 1
XLogP
2.7
TPSA
89.1 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
32

SMILES COC1=CC(=CC(=C1)N2CCN(CC2)C(=O)NC3=NC4=C(C=CC(=C4)F)N=C3OC)OC

Computed descriptors from PubChem (CID 11619093), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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