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Chemical structure of RA-9

GC60317

RA-9

Also known as (3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]piperidin-4-one

RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity· RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity· RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors· RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells

ChemicalCAS919091-63-7MW365.34FormulaC19H15N3O5
CAS number
919091-63-7
Molecular weight
365.34
Formula
C19H15N3O5
Solubility
DMSO： 4·17 mg/mL (11·41 mM; ultrasonic and warming and heat to 80°C)
InChIKey
YUYPWAMLWZVHAE-KAVGSWPWSA-N
Catalogue number
GC60317
Brand
GLPBIO
Computed properties PubChem CID 5469266 · XLogP 2.8 · TPSA 121 Ų · H-bond donors 1
XLogP
2.8
TPSA
121 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
2
Heavy atoms
27

SMILES C\1NC/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C1=C/C3=CC=C(C=C3)[N+](=O)[O-]

Computed descriptors from PubChem (CID 5469266), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.