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Chemical structure of Poloppin

GC60294

Poloppin

Also known as 3-[5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]pyrrol-2-yl]propanoic acid

Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26·9?μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29·5?μM)· Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis·?Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors

ChemicalCAS683808-78-8MW438.24FormulaC20H15BrF3NO2
CAS number
683808-78-8
Molecular weight
438.24
Formula
C20H15BrF3NO2
InChIKey
OCUKOJUZSNFVFQ-UHFFFAOYSA-N
Catalogue number
GC60294
Brand
GLPBIO
Computed properties PubChem CID 2289359 · XLogP 5.4 · TPSA 42.2 Ų · H-bond donors 1
XLogP
5.4
TPSA
42.2 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
27

SMILES C1=CC=C(C(=C1)C(F)(F)F)N2C(=CC=C2C3=CC=C(C=C3)Br)CCC(=O)O

Computed descriptors from PubChem (CID 2289359), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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