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Chemical structure of Maleimido-tri(ethylene glycol)-propionic acid

GC60236

Maleimido-tri(ethylene glycol)-propionic acid

Also known as 3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)· Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation· Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs

ChemicalCAS518044-40-1MW301.29FormulaC13H19NO7
CAS number
518044-40-1
Molecular weight
301.29
Formula
C13H19NO7
InChIKey
AMOPUHDFPSFVHL-UHFFFAOYSA-N
Catalogue number
GC60236
Brand
GLPBIO
Computed properties PubChem CID 53482093 · XLogP -2.1 · TPSA 135 Ų · H-bond donors 4
XLogP
-2.1
TPSA
135 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
21

SMILES C1=CC(=O)N(C1=O)C(CCO)C(CCO)(CCO)C(=O)O

Computed descriptors from PubChem (CID 53482093), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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