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Chemical structure of Lenalidomide-OH

GC60223

Lenalidomide-OH

Also known as 3-(6-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein· Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620

ChemicalCAS1416990-08-3MW260.25FormulaC13H12N2O4
CAS number
1416990-08-3
Molecular weight
260.25
Formula
C13H12N2O4
InChIKey
JJUMFQGCQAUIFH-UHFFFAOYSA-N
Catalogue number
GC60223
Brand
GLPBIO
Computed properties PubChem CID 71517902 · XLogP -0.2 · TPSA 86.7 Ų · H-bond donors 2
XLogP
-0.2
TPSA
86.7 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
19

SMILES C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)O

Computed descriptors from PubChem (CID 71517902), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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