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Chemical structure of BIX NHE1 inhibitor

GC50659

BIX NHE1 inhibitor

Also known as 4-(1-acetylpiperidin-4-yl)-N-(diaminomethylidene)-3-(trifluoromethyl)benzamide;hydrochloride

BIX NHE1 inhibitor is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively

ChemicalCAS1422252-46-7MW392.8FormulaC16H19F3N4O2·HCl
CAS number
1422252-46-7
Molecular weight
392.8
Formula
C16H19F3N4O2·HCl
Solubility
DMSO|19·64|50|
InChIKey
SLSZLEROFKLICF-UHFFFAOYSA-N
Catalogue number
GC50659
Brand
GLPBIO
Computed properties PubChem CID 121513866 · TPSA 102 Ų · H-bond donors 3 · H-bond acceptors 5
TPSA
102 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
26

SMILES CC(=O)N1CCC(CC1)C2=C(C=C(C=C2)C(=O)N=C(N)N)C(F)(F)F.Cl

Computed descriptors from PubChem (CID 121513866), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.