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Chemical structure of Didemnin B

GC49153

Didemnin B

Also known as (2S)-N-[(2R)-1-[[(3S,6S,8S,12S,13R,16S,17R,20S,23S)-13-[(2S)-butan-2-yl]-12-hydroxy-20-[(4-methoxyphenyl)methyl]-6,17,21-trimethyl-3-(2-methylpropyl)-2,5,7,10,15,19,22-heptaoxo-8-propan-2-yl-9,18-dioxa-1,4,14,21-tetrazabicyclo[21.3.0]hexacosan-16-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-[(2S)-2-hydroxypropanoyl]-N-methylpyrrolidine-2-carboxamide

Didemnin B is a cyclic depsipeptide produced by marine tunicates that specifically binds the GTP-bound conformation of EEF1A, inhibiting its release from the ribosomal A site and preventing subsequent peptide elongation

ChemicalCAS77327-05-0MW1112.4FormulaC57H89N7O15
CAS number
77327-05-0
Molecular weight
1112.4
Formula
C57H89N7O15
Solubility
Acetonitrile： 1 mg/ml
InChIKey
KYHUYMLIVQFXRI-SJPGYWQQSA-N
Catalogue number
GC49153
Brand
GLPBIO
Computed properties PubChem CID 122651 · XLogP 5.5 · TPSA 288 Ų · H-bond donors 5
XLogP
5.5
TPSA
288 Ų
H-bond donors
5
H-bond acceptors
15
Rotatable bonds
15
Heavy atoms
79

SMILES CC[C@H](C)[C@@H]1[C@H](CC(=O)O[C@H](C(=O)[C@@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]3CCCN3C(=O)[C@H](C)O)C)CC4=CC=C(C=C4)OC)C)CC(C)C)C)C(C)C)O

Computed descriptors from PubChem (CID 122651), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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