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Chemical structure of Pitstop2

GC45549

Pitstop2

Also known as N-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide

Pitstop2 is a clathrin inhibitor that inhibits amphoteric binding of clathrin terminal domains with an IC50 value of 12μM

ChemicalCAS1419320-73-2MW473.4FormulaC20H13BrN2O3S2
CAS number
1419320-73-2
Molecular weight
473.4
Formula
C20H13BrN2O3S2
Solubility
20mg/mL in DMSO
InChIKey
CGDLWHGPJPVPDU-ATVHPVEESA-N
Catalogue number
GC45549
Brand
GLPBIO
Computed properties PubChem CID 137254289 · XLogP 5.5 · TPSA 109 Ų · H-bond donors 1
XLogP
5.5
TPSA
109 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
3
Heavy atoms
28

SMILES C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)/C(=C/C4=CC=C(C=C4)Br)/S3

Computed descriptors from PubChem (CID 137254289), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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