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Chemical structure of LAS191859

GC44035

LAS191859

Also known as 2-[1-[2-[[cyclopropanecarbonyl(ethyl)amino]methyl]-4-(trifluoromethyl)phenyl]-6-methylpyrrolo[2,3-b]pyridin-3-yl]acetic acid

LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9·58, 14, 15·5, and 7·6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively

ChemicalCAS1420071-13-1MW459.5FormulaC24H24F3N3O3
CAS number
1420071-13-1
Molecular weight
459.5
Formula
C24H24F3N3O3
Solubility
DMF： 20 mg/ml,DMSO： 20 mg/ml,DMSO：PBS (pH 7·2) (1：2)： 0·33 mg/ml,Ethanol： 2·5 mg/ml
InChIKey
KGBYKYDRYYERIX-UHFFFAOYSA-N
Catalogue number
GC44035
Brand
GLPBIO
Computed properties PubChem CID 71222485 · XLogP 3.8 · TPSA 75.4 Ų · H-bond donors 1
XLogP
3.8
TPSA
75.4 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES CCN(CC1=C(C=CC(=C1)C(F)(F)F)N2C=C(C3=C2N=C(C=C3)C)CC(=O)O)C(=O)C4CC4

Computed descriptors from PubChem (CID 71222485), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.