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Chemical structure of HA-1077 (hydrochloride)

GC43803

HA-1077 (hydrochloride)

Also known as 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;dihydrochloride

Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0·33 μM for ROCK1, IC50s of 0·158 μM and 4·58 μM, 12·30 μM, 1·650 μM for ROCK2 and PKA, PKC, PKG, respectively· HA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator

ChemicalCAS203911-27-7MW364.3FormulaC14H17N3O2S•2HCl
CAS number
203911-27-7
Molecular weight
364.3
Formula
C14H17N3O2S•2HCl
Solubility
DMF： 2 mg/ml,DMSO： 3 mg/ml,PBS (pH 7·2)： 5 mg/ml
InChIKey
NOXXIYDYFSNHDF-UHFFFAOYSA-N
Catalogue number
GC43803
Brand
GLPBIO
Computed properties PubChem CID 16219471 · TPSA 70.7 Ų · H-bond donors 3 · H-bond acceptors 5
TPSA
70.7 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
2
Heavy atoms
22

SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl

Computed descriptors from PubChem (CID 16219471), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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