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Chemical structure of eCF309

GC43585

eCF309

Also known as 5-[4-amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine

eCF309 is an ATP-competitive inhibitor of mTOR (IC50 = 15 nM in vitro and in cells) with >65-fold selectivity over other kinases, including PI3Ks

ChemicalCAS2001571-40-8MW383.4FormulaC18H21N7O3
CAS number
2001571-40-8
Molecular weight
383.4
Formula
C18H21N7O3
Solubility
DMF： 1·6 mg/mL,DMSO： 2 mg/mL,DMSO：PBS (pH 7·2) (1：10)： 0·09 mg/mL
InChIKey
PSICWGWNIOOULV-UHFFFAOYSA-N
Catalogue number
GC43585
Brand
GLPBIO
Computed properties PubChem CID 122163152 · XLogP 1.5 · TPSA 140 Ų · H-bond donors 2
XLogP
1.5
TPSA
140 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
28

SMILES CCOC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OCC

Computed descriptors from PubChem (CID 122163152), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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