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Chemical structure of Compound 43 TAO Kinase Inhibitor

GC43304

Compound 43 TAO Kinase Inhibitor

Also known as N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively)

ChemicalCAS850467-66-2MW384.5FormulaC25H24N2O2
CAS number
850467-66-2
Molecular weight
384.5
Formula
C25H24N2O2
Solubility
DMSO: 100 mM,Ethanol: 20 mM
InChIKey
WQKXOAJVNFOHNZ-UHFFFAOYSA-N
Catalogue number
GC43304
Brand
GLPBIO
Computed properties PubChem CID 46673962 · XLogP 4.4 · TPSA 58.2 Ų · H-bond donors 2
XLogP
4.4
TPSA
58.2 Ų
H-bond donors
2
H-bond acceptors
2
Rotatable bonds
5
Heavy atoms
29

SMILES C1CC(C2=CC=CC=C2C1)NC(=O)CNC(=O)C3=CC=C(C=C3)C4=CC=CC=C4

Computed descriptors from PubChem (CID 46673962), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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