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Chemical structure of CI-898 (hydrochloride)

GC43267

CI-898 (hydrochloride)

Also known as 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine;trihydrochloride

Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4·74 nM and 1·35 nM for human DHFR and Toxoplasma gondii DHFR

ChemicalCAS1658520-97-8MW478.8FormulaC19H23N5O3•3HCl
CAS number
1658520-97-8
Molecular weight
478.8
Formula
C19H23N5O3•3HCl
Solubility
Soluble in DMSO
InChIKey
ZNJRHEVYOYMEHR-UHFFFAOYSA-N
Catalogue number
GC43267
Brand
GLPBIO
Computed properties PubChem CID 45006154 · TPSA 118 Ų · H-bond donors 6 · H-bond acceptors 8
TPSA
118 Ų
H-bond donors
6
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
30

SMILES CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC.Cl.Cl.Cl

Computed descriptors from PubChem (CID 45006154), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.