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Chemical structure of Chk2 Inhibitor

GC43239

Chk2 Inhibitor

Also known as 5-(2-amino-4-hydroxy-1H-imidazol-5-yl)-3,4-dihydro-2H-azepino[3,4-b]indol-1-one

Chk2 Inhibitor (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13·5 nM and 220·4 nM for Chk2 and Chk1, respectively· Chk2 Inhibitor can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect

ChemicalCAS724708-21-8MW295.3FormulaC15H13N5O2
CAS number
724708-21-8
Molecular weight
295.3
Formula
C15H13N5O2
Solubility
Soluble in DMSO
InChIKey
RZEPRPGFGRQXDI-UHFFFAOYSA-N
Catalogue number
GC43239
Brand
GLPBIO
Computed properties PubChem CID 135433657 · XLogP 0.3 · TPSA 116 Ų · H-bond donors 4
XLogP
0.3
TPSA
116 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
1
Heavy atoms
22

SMILES C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O

Computed descriptors from PubChem (CID 135433657), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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