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Chemical structure of BPIQ-II (hydrochloride)

GC42968

BPIQ-II (hydrochloride)

Also known as N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine;hydrochloride

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM)

ChemicalCAS171179-37-6MW376.6FormulaC15H10BrN5•HCl
CAS number
171179-37-6
Molecular weight
376.6
Formula
C15H10BrN5•HCl
Solubility
DMF： 10 mg/ml,DMSO： 30 mg/ml,DMSO：PBS (pH 7·2)(1：9)： 0·1 mg/ml
InChIKey
FENLVGDZGJBHPT-UHFFFAOYSA-N
Catalogue number
GC42968
Brand
GLPBIO
Computed properties PubChem CID 132988087 · TPSA 66.5 Ų · H-bond donors 3 · H-bond acceptors 4
TPSA
66.5 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
22

SMILES C1=CC(=CC(=C1)Br)NC2=NC=NC3=CC4=C(C=C32)NC=N4.Cl

Computed descriptors from PubChem (CID 132988087), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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