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Chemical structure of SGK1 Inhibitor

GC40046

SGK1 Inhibitor

Also known as N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide

SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2 (IC50s = 4·8 and 2·8 nM, respectively)

ChemicalCAS1426214-51-8MW435.3FormulaC17H12Cl2N6O2S
CAS number
1426214-51-8
Molecular weight
435.3
Formula
C17H12Cl2N6O2S
Solubility
Soluble in DMSO
InChIKey
MBNNXCKHRKSGSU-UHFFFAOYSA-N
Catalogue number
GC40046
Brand
GLPBIO
Computed properties PubChem CID 71536970 · XLogP 2.9 · TPSA 135 Ų · H-bond donors 3
XLogP
2.9
TPSA
135 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
28

SMILES C1=CC(=C(C(=C1)Cl)Cl)S(=O)(=O)NC2=CC=C(C=C2)C3=NC4=NNC(=C4N=C3)N

Computed descriptors from PubChem (CID 71536970), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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