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Chemical structure of (Z)-4EGI-1

GC39842

(Z)-4EGI-1

Also known as (2Z)-2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation· (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43·5 μM and a Kd value of 8·74 μM· (Z)-4EGI-1 has anticancer activity

ChemicalCAS901787-88-0MW451.28FormulaC18H12Cl2N4O4S
CAS number
901787-88-0
Molecular weight
451.28
Formula
C18H12Cl2N4O4S
Solubility
DMSO： 50 mg/mL (110·80 mM; ultrasonic and warming and heat to 60°C)
InChIKey
KFRKRECSIYXARE-HMAPJEAMSA-N
Catalogue number
GC39842
Brand
GLPBIO
Computed properties PubChem CID 6911989 · XLogP 6.1 · TPSA 149 Ų · H-bond donors 2
XLogP
6.1
TPSA
149 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
29

SMILES C1=CC=C(C(=C1)C/C(=N/NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)/C(=O)O)[N+](=O)[O-]

Computed descriptors from PubChem (CID 6911989), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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