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Chemical structure of AMI-1 free acid

GC39840

AMI-1 free acid

Also known as 4-hydroxy-7-[(5-hydroxy-7-sulfonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonic acid

AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8·8 μM and 3·0 μM for human PRMT1 and yeast-Hmt1p, respectively· AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding

ChemicalCAS134-47-4MW504.49FormulaC21H16N2O9S2
CAS number
134-47-4
Molecular weight
504.49
Formula
C21H16N2O9S2
Solubility
DMSO: 83·33 mg/mL (165·18 mM)
InChIKey
PCGISRHGYLRXSR-UHFFFAOYSA-N
Catalogue number
GC39840
Brand
GLPBIO
Computed properties PubChem CID 67254 · XLogP 1.8 · TPSA 207 Ų · H-bond donors 6
XLogP
1.8
TPSA
207 Ų
H-bond donors
6
H-bond acceptors
9
Rotatable bonds
4
Heavy atoms
34

SMILES C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)S(=O)(=O)O)S(=O)(=O)O)O

Computed descriptors from PubChem (CID 67254), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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