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Chemical structure of THZ-P1-2

GC39823

THZ-P1-2

Also known as 4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[3-[[6-(1H-indol-3-yl)pyrimidin-4-yl]amino]phenyl]benzamide

THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα· THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ· THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling· THZ-P1-2 displays anticancer activity in leukemia cell lines

ChemicalCAS2058075-45-7MW531.61FormulaC31H29N7O2
CAS number
2058075-45-7
Molecular weight
531.61
Formula
C31H29N7O2
Solubility
Soluble in DMSO
InChIKey
MJJJRRMQCUUKEO-IZZDOVSWSA-N
Catalogue number
GC39823
Brand
GLPBIO
Computed properties PubChem CID 134451950 · XLogP 4.2 · TPSA 115 Ų · H-bond donors 4
XLogP
4.2
TPSA
115 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
40

SMILES CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)C4=CNC5=CC=CC=C54

Computed descriptors from PubChem (CID 134451950), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.